| Customization: | Available |
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| CAS No.: | 497-30-3 |
| Formula: | C9h15n3o2s |
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L-Ergothioneine is an amino acid that is found mainly in mushrooms, but also in king crab, meat from animals that have grazed on grasses containing L-Ergothioneinethioneine, and other foods. Amino acids are chemicals that are the building blocks for proteins. L-Ergothioneinethioneine is used as medicine.
L-Ergothioneinethioneine is sometimes applied directly to the skin to prevent wrinkles, reduce signs of aging skin, and reduce sun damage.
| Product name | L-Ergothioneine |
| CAS NUMBER | 497-30-3 |
| Application | Cosmetics, food, dietary supplements, health products and biomedicine |
| Service | Free sample, Ready to Ship, Drop Shipping service, Excellent Customs clearance Ability MSDS, COA,TDS available |
EINECS NUMBER: 207-843-5
M.F.: C9H15N3O2S
M.W.: 229.3
Purity: 99%
Appearance: White Powder
MOQ: 10 grams
L-Ergothioneinethioneine levels in the body
Another factor that suggests how important L-Ergothioneine is to human health is how efficient the human body is in concentrating and holding on to this compound. If L-Ergothioneine were unimportant, it would not be concentrated and retained so efficiently.
In particular, body tissues highly active in energy metabolism and susceptible to oxidative stress and inflammation contain the richest concentration of L-Ergothioneine. Specifically, the brain, liver, intestinal cells, testes, bone marrow, kidney, spleen, lung, and eyes. Tissues that L-Ergothioneine is also found in higher concentrations in seminal fluid and breast milk. Again, all of this data indicates L-Ergothioneine may be an essential vitamin.
L-Ergothioneinethioneine and Healthy Aging
The brain may be the most sensitive to low L-Ergothioneine levels in the tissues where L-Ergothioneine is concentrated. After all, the brain is the most metabolically active tissue in the body. The decline in brain function with aging might eventually be linked to lowered L-Ergothioneine status and be one of the signs of an L-Ergothioneine deficiency if it is established as a vitamin.
Levels of L-Ergothioneine decrease with age due to both a drop in dietary intake and a decrease in the genetic expression for the L-Ergothioneine transport proteins. This scenario indicates that L-Ergothioneine deficiency may significantly affect aging-related impaired brain function. There is data to support this connection, as two human studies show L-Ergothioneine is lower in elderly patients with mild cognitive impairment than those without. And there is evidence that L-Ergothioneine accumulates in the brain, where it may protect against oxidative damage, inflammation, and decreased mitochondrial function linked to cognitive decline in older adults.
Frailty is another condition associated with aging, and when researchers sought to determine the metabolic basis of frailty, L-Ergothioneine levels were significantly lower in frail elderly subjects compared to the non-frail elderly subjects.
And another study showed that L-Ergothioneine levels were associated with the preservation of gait (manner of walking). Disturbance in gait is a common sign of aging. The basis of gait disturbance in older adults is oxidative damage of skeletal muscle. L-Ergothioneine appears to help protect against this underlying damage.
L-Ergothioneine has been shown to decrease oxidative stress in virtually every tissue and cell type studied, including the lining of blood vessels, liver, kidney, heart, and other organs. It also helps reduce the toxic effects of many harmful chemicals. L-Ergothioneine antioxidant and detoxification effects are at its core in all applications. It is particularly well-suited for protecting the heart and vascular system and against the increased oxidative stress associated with diabetes and obesity.
Food Sources of L-Ergothioneinethioneine
Lower intakes of L-Ergothioneine from the diet may explain why Americans have more age-related health issues and a lower life expectancy than other countries. For example, the estimated intake level of L-Ergothioneine in the United States is 1.1 mg/day compared to up to 4.6 mg/day in Italy.
When researchers analyzed a twenty-year study of the dietary habits of over 15,000 American participants, they found that individuals that consumed even small amounts of mushrooms had a 16% reduction in their mortality rate and a 35% reduced rate if mushroom intake was coupled with a lower red meat intake.
L-Ergothioneine may be the key mushroom component for this benefit.
All foods have at least trace levels of L-Ergothioneine. But the common conventional agricultural practice of excessive soil tillage may be why dietary levels may be much lower now. Excessive tillage disrupts the fungal mycelia in the soil that feeds crops nutrients, including L-Ergothioneine.
Mushrooms are the key dietary source of L-Ergothioneine, representing about 95% of the total dietary intake. Other foods with modest levels of L-Ergothioneine include oat bran, black or red beans, and organ meats (e.g., liver and kidney). The L-Ergothioneine content of mushrooms varies considerably based on variety. A 3-ounce serving of crimini, portabella, or button mushrooms has an L-Ergothioneine content of roughly 5 mg.
Shiitake, oyster, lion's mane, or maitake mushrooms have a higher L-Ergothioneine content of up to 13 mg per 3-ounce serving. Cooking does not diminish the L-Ergothioneine content, and studies show that ingesting mushrooms raises blood levels of L-Ergothioneine.
Since mushrooms are by far the primary dietary source, if a person is not regularly eating mushrooms, they are likely deficient in L-Ergothioneine. And evidence indicates that it could accelerate aging and the development of age-related disorders.
L-Ergothioneinethioneine as a Dietary Supplement
Taking supplemental L-Ergothioneinethioneine may be a good option, given its safety and the possible health benefits of raising the intake of L-Ergothioneine.
Regarding the safety of L-Ergothioneine, it has undL-Ergothioneinene extensive studies to determine safety. Even at extremely large doses, no adverse effects were seen in animal studies. And the recommended supplemental dosage level of 30 mg per day is well below the no observed adverse effect level (NOAEL) of 800 mg per kg body weight per day established by the European Food Safety Authority (EFSA). L-Ergothioneine has also been established as Generally Recognized as Safe (GRAS) by the U.S. Food and Drug Administration (FDA).
A human clinical trial verified the effectiveness of L-Ergothioneine as a dietary supplement showing that it is absorbed and retained in the body based upon increased levels of L-Ergothioneine in the red blood cells (preferentially) and plasma combined with minimal excretion in the urine (less than 4% of oral dosage). The increase in L-Ergothioneine was associated with a downward trend in inflammation and oxidative damage biomarkers.
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Shaanxi Afterglow Bioindustry Co.,Ltd was established in 2006, and located in Shaanxi Province, China. We are professional supplier of Fine chemicals, raw material for cosmetics, Food Additives, Nutritional supplement, Herbal/Animal Extract and Essential Oil.
As the predecessor of the County Institute of Traditional Chinese Medicine,We offer various OEM services with GMP standards, Meanwhile, the factory is equipped with the researching and quality test laboratory, and we have good relationship with several universities.
With more than ten years of export experience, quick response, good after-sale service, high product quality, and reasonable prices are the concepts that we always insisted on.
We uphold a consistent level of professionalism, quality, reliability and service, therefore we are always ready for cooperation and gladly welcome you.
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