| Customization: | Available |
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| Certification: | RoHS, BRC, ISO, FDA, HACCP |
| Assay Method: | HPLC-MS, GPC, HPLC, UV |
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Product Description
Camptothecin (CPT) is a cytotoxic quino line alkaloid which inhibits the DNA enzyme topoisomerase I (topo I). It was discovered in 1966 by M. E. Wall and M. C. Wani in systematic screening of natural products for anticancer drugs. It was isolated from the bark and stem of Camptotheca acuminata (Camptotheca, Happy tree), a tree native to China used as a cancer treatment in Traditional Chinese Medicine.
CPT showed remarkable anticancer activity in preliminary clinical trials but also low solubility and (high) adverse drug reaction. Because of these disadvantages synthetic and medicinal chemists have developed numerous syntheses of Camptothecin and various derivatives to increase the benefits of the chemical, with good results. Two CPT analogues have been approved and are used in cancer chemotherapy today, topotecan and irinotecan.
Camptotheca acuminata (scientific name: Camptotheca acuminata.), also known as hanlian, Shuili, shuitongshu, Tianzi, hanlianzi, qianzhangshu, yebajiao, shuimozi, is a blue fruit family, Camptotheca plants.
| Producut name: | Camptothecin |
| CAS NO. | 7689-03-4 |
| Appearance: | Light Yellow Crystalline Powder |
| Service | Ready to Ship, Drop Shipping service, Excellent Customs clearance Ability MSDS, COA,TDS available OEM Capsule form |
Purity: 98% HPLC
Boiling Point: 482.73°c
Melting Point: 260 °c (DEC.)(Lit.)
Molecular Formula: C20h16n2o4
Source: Camptotheca acuminata Extract
MOQ: 10 Grams
Hydroxycamptothecin also available
Application
1. Applied in the functional food field;
2. Applied in the health product field;
3. Applied in the pharmaceutical field.
1) Camptothecin and its derivatives are unique in their ability to inhibit DNA Topoisomerase I, by stabilizing a covalent reaction intermediate termed the cleavable complex which ultimately causes tumor cell death.
2) In clinical it is widely believed that camptothecin analogs exhibited remarkable anti-tumour and anti-leukaemia activity. Topoisomerase is a basilic enzyme in the process of DNA replication,
it is responsible for the winding / unwinding of the supercoiled DNA composing the chromosomes. If the chromosomes cannot be unwound, transcription of DNA message cannot occur and the protein cannot be synthesized, it ultimately causes cell death.
3) Application of camptothecin in clinic is limited due to serious side effects and poor water-solubility. 4.At present, some camptothecin analogs,either semi-synthetic or synthetic drug based on camptothecin, have been applied cancerous therapy such as topotecan and irinotecan while others have been obtained satisfying curative effects in clinic.
Shaanxi Afterglow Bioindustry Co.,Ltd was established in 2006, and located in Shaanxi Province, China. We are professional supplier of Fine chemicals, raw material for cosmetics, Food Additives, Nutritional supplement, Herbal/Animal Extract and Essential Oil.
As the predecessor of the County Institute of Traditional Chinese Medicine,We offer various OEM services with GMP standards, Meanwhile, the factory is equipped with the researching and quality test laboratory, and we have good relationship with several universities.
With more than ten years of export experience, quick response, good after-sale service, high product quality, and reasonable prices are the concepts that we always insisted on.
We uphold a consistent level of professionalism, quality, reliability and service, therefore we are always ready for cooperation and gladly welcome you.
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